MIGA1

Across TCGA cell cohorts, MIGA1 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible MIGA1-associated genes across cancer lineages are PRM2, USP29, and TAAR8. Each is linked with MIGA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MIGA1-to-partner and partner-to-MIGA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRM2 grouped by MIGA1-low versus MIGA1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIGA1→partner) and Y-score (partner→MIGA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PRM2 →	+0.028	+4.681	<.001	.003	3	1
LUNG_NSCLC_LUAD	USP29 →	+0.009	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	TAAR8 →	+0.011	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	RBMXL2 →	+0.040	+3.920	<.001	.005	3	1
LUNG_NSCLC_LUAD	SULT1C3 →	+0.037	+3.947	.005	.004	3	1
LUNG_NSCLC_LUAD	CT47A1 →	+0.028	+4.681	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

PRM2 by MIGA1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →