MIER3

Across TCGA pan-cancer cohorts, MIER3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated MIER3 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher MIER3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MIER3 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

UCEC, HNSC, and LUAD are the cancer types where MIER3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.941	0.556	.016	16	view →
HNSC	DFS	Quartile	II,III,IV	1.000	0.895	.015	14	view →
LUAD	OS	Tertile	All	1.000	0.388	.014	8	view →
CCRCC	DFS	Median	III,IV	0.269	0.870	.005	7	view →
GBM	OS	Quartile	All	0.840	0.449	.027	2	view →
LSCC	DFS	Median	All	0.869	0.713	.027	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

MIER3–UCEC (DFS)

Open the UCEC breakdown →