MIER3

Across TCGA patient cohorts, MIER3 mutation is significantly associated with the RNA expression of many other genes, with 2,279 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MIER3-associated genes across cancer lineages are RNU6-1245P, RNA5SP131, and POLR2DP1. Each is linked with MIER3 in more than 2 cancer types. Because this analysis shows association rather than direction, both MIER3-to-partner and partner-to-MIER3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1245P grouped by MIER3-low versus MIER3-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIER3→partner) and Y-score (partner→MIER3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU6-1245P →	+0.346	+5.060	<.001	.001	3	3
CESC	RNA5SP131 →	+0.303	+5.342	<.001	.002	3	2
CESC	POLR2DP1 →	+0.078	+4.669	<.001	.007	3	2
CESC	LINC00550 →	+0.015	+5.424	.002	<.001	3	2
READ	OR52T1P →	+0.140	+5.925	<.001	.002	3	2
COAD	RPL30P1 →	+0.403	+3.184	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,279 associations by consensus.

RNU6-1245P by MIER3 expression — CESC

Explore this box plot interactively →