MIER3

Across TCGA patient cohorts, MIER3 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MIER3-associated genes across cancer lineages are ERK2, Chk2_pT68, and C-Raf. Each is linked with MIER3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MIER3-to-partner and partner-to-MIER3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by MIER3-low versus MIER3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIER3→partner) and Y-score (partner→MIER3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.196	+1.584	.009	.036	3	2
UCEC	Chk2_pT68 →	-0.184	-3.295	.011	.009	3	2
UCEC	C-Raf →	+0.162	+2.115	.003	.017	3	2
UCEC	14-3-3_beta →	-0.098	-3.295	.012	.009	3	1
UCEC	FoxM1 →	+0.208	+2.000	.040	.010	3	1
UCEC	Gab2 →	+0.399	+2.000	.004	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

ERK2 by MIER3 expression — UCEC

Explore this box plot interactively →