MIER3

Across TCGA cell cohorts, MIER3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,018 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MIER3-associated GO terms across cancer lineages are Regulation of maintenance of sister chromatid cohesion, Regulation of maintenance of mitotic sister chromatid cohesion, and Positive regulation of DNA repair. Each is linked with MIER3 in more than 14 cancer types. Because this analysis shows association rather than direction, both MIER3-to-partner and partner-to-MIER3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of maintenance of sister chromatid cohesion grouped by MIER3-low versus MIER3-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MIER3→partner) and Y-score (partner→MIER3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Regulation of maintenance of sister chromatid cohesion →	+0.153	+0.935	<.001	<.001	3	15
SOFT_TISSUE	Regulation of maintenance of mitotic sister chromatid cohesion →	+0.153	+0.935	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Positive regulation of DNA repair →	+0.080	+1.290	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Centrosome cycle →	+0.093	+1.017	<.001	<.001	3	15
OVARY	Heterochromatin organization →	+0.071	+0.803	<.001	.001	3	14
UPPER_AERODIGESTIVE_TRACT	Positive regulation of organelle assembly →	+0.069	+1.049	<.001	.003	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,018 associations by consensus.

Regulation of maintenance of sister chromatid cohesion by MIER3 expression — SOFT_TISSUE

Explore this box plot interactively →