MIER3

Across TCGA cell cohorts, MIER3 mutation is significantly associated with the drug of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MIER3-associated genes across cancer lineages are Teniposide, 50869, and GSK1059615. Each is linked with MIER3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MIER3-to-partner and partner-to-MIER3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Teniposide grouped by MIER3-low versus MIER3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIER3→partner) and Y-score (partner→MIER3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Teniposide →	+0.531	+2.649	.047	.046	1	1
LARGE_INTESTINE	50869 →	+0.513	+2.649	.014	.046	1	1
LARGE_INTESTINE	GSK1059615 →	+0.662	+2.652	.004	.045	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Teniposide by MIER3 expression — LARGE_INTESTINE

Explore this box plot interactively →