MIER2

Across TCGA patient cohorts, MIER2 mutation is significantly associated with the RNA expression of many other genes, with 1,545 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MIER2-associated genes across cancer lineages are MIR4510, MPPE1, and ZC3H18. Each is linked with MIER2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MIER2-to-partner and partner-to-MIER2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4510 grouped by MIER2-low versus MIER2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIER2→partner) and Y-score (partner→MIER2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MIR4510 →	+0.300	+5.342	<.001	.002	3	2
UCEC	MPPE1 →	+0.542	+2.290	<.001	.001	3	2
UCEC	ZC3H18 →	+0.429	+2.280	<.001	.001	3	2
UCEC	FOXK1 →	+0.496	+1.890	.006	.005	3	2
UCEC	GOLGA2 →	+0.475	+2.463	<.001	.001	3	2
UCEC	URM1 →	+0.338	+2.008	.004	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,545 associations by consensus.

MIR4510 by MIER2 expression — CESC

Explore this box plot interactively →