MIER2

Across TCGA patient cohorts, MIER2 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MIER2-associated genes across cancer lineages are Annexin-1, Lck, and mTOR_pS2448. Each is linked with MIER2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MIER2-to-partner and partner-to-MIER2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by MIER2-low versus MIER2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIER2→partner) and Y-score (partner→MIER2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.576	+2.000	.004	.029	3	3
UCEC	Lck →	+0.226	+1.678	.003	.023	3	2
UCEC	mTOR_pS2448 →	-0.130	-3.308	.023	.009	3	2
UCEC	ATM →	-0.345	-1.678	.047	.023	3	2
UCEC	Caspase-7-cleavedD198 →	+0.585	+2.459	.010	.018	3	2
UCEC	Di-Ras3 →	-0.114	-3.156	.045	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Annexin-1 by MIER2 expression — UCEC

Explore this box plot interactively →