MIER2

Across TCGA cell cohorts, MIER2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,072 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MIER2-associated GO terms across cancer lineages are Cytoplasm protein quality control, Positive regulation of anaphase-promoting complex-dependent catabolic process, and Viral translational termination-reinitiation. Each is linked with MIER2 in more than 13 cancer types. Because this analysis shows association rather than direction, both MIER2-to-partner and partner-to-MIER2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cytoplasm protein quality control grouped by MIER2-low versus MIER2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MIER2→partner) and Y-score (partner→MIER2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Cytoplasm protein quality control →	+0.194	+1.223	<.001	<.001	3	14
BONE	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.200	+1.160	.001	<.001	3	14
STOMACH	Viral translational termination-reinitiation →	+0.088	+0.989	<.001	<.001	3	14
LUNG_SCLC	Regulation of glucose mediated signaling pathway →	+0.132	+0.761	.004	<.001	3	13
LUNG_SCLC	Positive regulation of glucose mediated signaling pathway →	+0.132	+0.761	.004	<.001	3	13
BONE	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.238	+1.423	.002	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,072 associations by consensus.

Cytoplasm protein quality control by MIER2 expression — BONE

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