MIER2

Across TCGA cell cohorts, MIER2 mutation is significantly associated with the RNA expression of many other genes, with 42 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MIER2-associated genes across cancer lineages are BIRC8, OR2T2, and TMEM114. Each is linked with MIER2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MIER2-to-partner and partner-to-MIER2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BIRC8 grouped by MIER2-low versus MIER2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIER2→partner) and Y-score (partner→MIER2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	BIRC8 →	+0.012	+4.977	<.001	.007	3	1
SKIN	OR2T2 →	+0.013	+4.977	<.001	.007	3	1
SKIN	TMEM114 →	+0.051	+4.977	<.001	.007	3	1
CNS	LALBA →	+0.050	+5.754	<.001	.002	3	1
BLOOD_Leukemia	ADAM2 →	+0.077	+4.539	.008	.007	3	1
BLOOD_Leukemia	TRAPPC3L →	+0.100	+4.152	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

BIRC8 by MIER2 expression — SKIN

Explore this box plot interactively →