Across TCGA patient cohorts, MIER1 protein abundance is significantly associated with the RNA expression of many other genes, with 12,055 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MIER1-associated genes across cancer lineages are USP33, USP1, and GZMK. Each is linked with MIER1 in more than 5 cancer types. Because this analysis shows association rather than direction, both MIER1-to-partner and partner-to-MIER1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIER1→partner) and Y-score (partner→MIER1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	USP33 →	+0.532	+0.160	<.001	<.001	3	6
BRCA	USP1 →	+0.702	+0.298	<.001	<.001	3	5
BRCA	GZMK →	+0.895	+0.193	<.001	.001	3	5
UCEC	CD3D →	+1.758	+0.254	<.001	<.001	3	5
UCEC	CD300LF →	+1.020	+0.210	<.001	.005	3	5
UCEC	ORC1 →	+0.873	+0.239	.007	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,055 associations by consensus.

Exploration

MIER1 survival (RNA) · tumor vs normal (RNA) · all MIER1 data types