MIEF2

Across TCGA patient cohorts, MIEF2 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MIEF2-associated genes across cancer lineages are Chk2_pT68, ERK2, and N-Cadherin. Each is linked with MIEF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MIEF2-to-partner and partner-to-MIEF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chk2_pT68 grouped by MIEF2-low versus MIEF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIEF2→partner) and Y-score (partner→MIEF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Chk2_pT68 →	-0.177	-2.990	.049	.036	3	2
UCEC	ERK2 →	+0.235	+2.459	.011	.020	3	1
UCEC	N-Cadherin →	+0.211	+3.584	.039	.002	2	2

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Chk2_pT68 by MIEF2 expression — UCEC

Explore this box plot interactively →