MIEF2

Across TCGA cell cohorts, MIEF2 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MIEF2-associated genes across cancer lineages are CCDC54, TBC1D21, and OR52H1. Each is linked with MIEF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MIEF2-to-partner and partner-to-MIEF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC54 grouped by MIEF2-low versus MIEF2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIEF2→partner) and Y-score (partner→MIEF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CCDC54 →	+0.135	+3.736	<.001	.004	3	1
LARGE_INTESTINE	TBC1D21 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	OR52H1 →	+0.025	+3.347	<.001	.005	3	1
LARGE_INTESTINE	WNT8A →	+0.018	+3.632	.007	.003	3	1
BLOOD_Leukemia	NKX2-6 →	+0.663	+5.201	<.001	.006	3	1
BLOOD_Leukemia	KRTAP21-2 →	+0.085	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

CCDC54 by MIEF2 expression — LARGE_INTESTINE

Explore this box plot interactively →