MID2

Across TCGA patient cohorts, MID2 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MID2-associated genes across cancer lineages are p38-MAPK_pT180_Y182, INPP4B, and MEK1. Each is linked with MID2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MID2-to-partner and partner-to-MID2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by MID2-low versus MID2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MID2→partner) and Y-score (partner→MID2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.298	-2.000	.038	.009	3	3
UCEC	INPP4B →	-0.222	-1.584	.031	.032	3	2
UCEC	MEK1 →	+0.418	+2.058	<.001	<.001	3	2
UCEC	Notch1 →	+0.205	+2.378	<.001	<.001	3	2
UCEC	PCNA →	+0.179	+1.777	.009	.002	3	2
UCEC	Rab25 →	-0.351	-1.777	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

p38-MAPK_pT180_Y182 by MID2 expression — UCEC

Explore this box plot interactively →