MID1

Across TCGA patient cohorts, MID1 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MID1-associated genes across cancer lineages are Notch1, PDCD4, and S6_pS240_S244. Each is linked with MID1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MID1-to-partner and partner-to-MID1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by MID1-low versus MID1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MID1→partner) and Y-score (partner→MID1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.148	+1.643	<.001	.003	3	2
UCEC	PDCD4 →	-0.468	-1.668	.001	.021	3	2
UCEC	S6_pS240_S244 →	+0.330	+1.906	.008	.015	3	2
UCEC	Caspase-8 →	-0.176	-1.636	.023	.009	3	2
UCEC	EGFR_pY1068 →	-0.217	-2.169	.005	.003	3	1
UCEC	eIF4E →	+0.138	+1.643	.035	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Notch1 by MID1 expression — UCEC

Explore this box plot interactively →