MICU3

Across TCGA patient cohorts, MICU3 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MICU3-associated genes across cancer lineages are ATM, PCNA, and Cyclin-D1. Each is linked with MICU3 in more than 2 cancer types. Because this analysis shows association rather than direction, both MICU3-to-partner and partner-to-MICU3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by MICU3-low versus MICU3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MICU3→partner) and Y-score (partner→MICU3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.719	-2.662	<.001	<.001	3	3
UCEC	PCNA →	+0.296	+3.584	<.001	.002	3	2
UCEC	Cyclin-D1 →	+0.146	+1.807	.015	.025	3	2
UCEC	eEF2 →	+0.306	+2.115	.022	.017	3	1
UCEC	EGFR_pY1068 →	-0.267	-3.459	.004	.005	3	1
UCEC	A-Raf_pS299 →	-0.116	-2.321	.009	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

ATM by MICU3 expression — UCEC

Explore this box plot interactively →