MICU1

Across TCGA patient cohorts, MICU1 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MICU1-associated genes across cancer lineages are MEK1, N-Ras, and VHL. Each is linked with MICU1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MICU1-to-partner and partner-to-MICU1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by MICU1-low versus MICU1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MICU1→partner) and Y-score (partner→MICU1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.414	+2.321	.024	.035	3	1
UCEC	N-Ras →	-0.136	-3.150	.023	.019	3	1
UCEC	VHL →	-0.829	-3.169	.015	.019	3	1
UCEC	14-3-3_beta →	-0.125	-2.308	.013	.036	2	1
UCEC	4E-BP1 →	+0.433	+3.029	.001	.018	2	1
UCEC	Di-Ras3 →	-0.196	-3.459	.008	.005	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

MEK1 by MICU1 expression — UCEC

Explore this box plot interactively →