MICOS10P4

Across TCGA pan-cancer cohorts, MICOS10P4 RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated MICOS10P4 data layer.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher MICOS10P4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MICOS10P4 expression acts as an unfavorable survival marker, although some lineages such as ESCA and KIRC show a favorable association.

READ, THCA, and DLBC are the cancer types where MICOS10P4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	DFS	Tertile	All	0.269	0.819	.009	45	view →
THCA	DFS	Tertile	All	0.400	0.847	<.001	39	view →
DLBC	OS	Tertile	III,IV	0.175	0.874	.025	36	view →
SARC	OS	Tertile	All	0.189	0.747	<.001	36	view →
THYM	DFS	Tertile	II,III,IV	0.075	0.851	<.001	27	view →
HNSC	DFS	Tertile	II,III,IV	0.194	0.661	.031	27	view →
LUAD	OS	Tertile	III,IV	0.223	0.677	.006	27	view →
UCEC	DFS	Tertile	All	0.758	0.900	.001	24	view →
ESCA	OS	Tertile	III,IV	0.831	0.367	.026	18	view →
KIRC	DFS	Tertile	III,IV	1.000	0.728	.016	12	view →
SKCM	OS	Tertile	All	0.496	0.787	.048	9	view →
STAD	DFS	Tertile	IV	0.083	0.379	.001	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

MICOS10P4–READ (DFS)

Open the READ breakdown →