Across TCGA pan-cancer cohorts, MICOS10P2 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of MICOS10P2’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where MICOS10P2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MICOS10P2 is over-expressed in tumor.
COAD and LIHC are the cancer types where MICOS10P2 tumor–normal differential expression is most reproducible.