MICOS10

Across TCGA cell cohorts, MICOS10 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,280 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MICOS10-associated GO terms across cancer lineages are Regulation of DNA stability, Cristae formation, and Regulation of metaphase/anaphase transition of cell cycle. Each is linked with MICOS10 in more than 10 cancer types. Because this analysis shows association rather than direction, both MICOS10-to-partner and partner-to-MICOS10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of DNA stability grouped by MICOS10-low versus MICOS10-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MICOS10→partner) and Y-score (partner→MICOS10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of DNA stability →	+0.139	+0.702	.001	.002	3	11
BLOOD_Leukemia	Cristae formation →	+0.088	+0.859	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Regulation of metaphase/anaphase transition of cell cycle →	+0.110	+0.915	.001	.001	3	9
BLOOD_Myeloma	Spindle elongation →	+0.148	+0.708	.006	.006	3	9
BLOOD_Myeloma	DNA-templated DNA replication →	+0.110	+0.980	<.001	.002	3	8
BLOOD_Myeloma	DNA replication checkpoint signaling →	+0.181	+1.143	.002	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,280 associations by consensus.

Regulation of DNA stability by MICOS10 expression — LUNG_SCLC

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