Across TCGA pan-cancer cohorts, MICC RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of MICC’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MICC RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MICC is over-expressed in tumor, although a few such as READ show the opposite, repressed pattern.

KIRC, BLCA, and HNSC are the cancer types where MICC tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MICC RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	II,III,IV	+0.074	<.001	11	view →
BLCA	All	All	+0.178	.019	4	view →
HNSC	All	All	+0.082	.004	4	view →
BRCA	All	All	+0.057	<.001	4	view →
READ	Female	All	−0.050	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: MICC RNA expression & survival · all MICC data types