Across TCGA patient cohorts, MICB mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MICB-associated genes across cancer lineages are Smad4, 14-3-3_beta, and EGFR_pY1068. Each is linked with MICB in more than 1 cancer types. Because this analysis shows association rather than direction, both MICB-to-partner and partner-to-MICB results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MICB→partner) and Y-score (partner→MICB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Smad4 →	-0.155	-3.439	.005	.005	3	2
UCEC	14-3-3_beta →	-0.161	-3.432	<.001	.005	3	1
UCEC	EGFR_pY1068 →	-0.313	-2.584	.007	.011	3	1
UCEC	JNK_pT183_Y185 →	-0.192	-2.571	.014	.011	3	1
UCEC	JNK2 →	+0.244	+3.009	.008	.019	3	1
UCEC	Ku80 →	+0.333	+3.713	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Exploration

MICB survival (RNA) · tumor vs normal (RNA) · all MICB data types