MICALL2

Across TCGA pan-cancer cohorts, MICALL2 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated MICALL2 data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher MICALL2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MICALL2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and CCRCC show a favorable association.

UCEC, LSCC, and GBM are the cancer types where MICALL2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.969	0.746	<.001	54	view →
LSCC	OS	Tertile	II,III,IV	0.633	0.966	<.001	33	view →
GBM	OS	Tertile	All	0.673	0.911	.001	13	view →
CCRCC	DFS	Tertile	III,IV	0.821	0.367	.011	9	view →
LUAD	DFS	Quartile	III,IV	0.195	0.723	.002	8	view →
PDAC	DFS	Quartile	III,IV	0.929	0.219	.006	7	view →
HNSC	DFS	Median	IV	0.915	1.000	.020	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

MICALL2–UCEC (DFS)

Open the UCEC breakdown →