MICALL2

Across TCGA patient cohorts, MICALL2 mutation is significantly associated with the RNA expression of many other genes, with 603 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MICALL2-associated genes across cancer lineages are TRIM49B, MRPS31P2, and MIR3908. Each is linked with MICALL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MICALL2-to-partner and partner-to-MICALL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIM49B grouped by MICALL2-low versus MICALL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MICALL2→partner) and Y-score (partner→MICALL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRIM49B →	+0.205	+2.255	.006	<.001	3	3
COAD	MRPS31P2 →	+0.315	+3.219	<.001	.005	3	2
COAD	MIR3908 →	+0.226	+5.412	<.001	.001	3	2
UCEC	MAP3K4-AS1 →	+0.795	+2.593	<.001	.006	3	2
CESC	LINC01519 →	+0.012	+3.254	<.001	.005	3	2
LUAD	POLR3KP2 →	+0.219	+5.410	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 603 associations by consensus.

TRIM49B by MICALL2 expression — UCEC

Explore this box plot interactively →