MICALL2

Across TCGA patient cohorts, MICALL2 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MICALL2-associated genes across cancer lineages are Bim, Bak, and Rab11. Each is linked with MICALL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MICALL2-to-partner and partner-to-MICALL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bim grouped by MICALL2-low versus MICALL2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MICALL2→partner) and Y-score (partner→MICALL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Bim →	-0.238	-3.000	.039	.035	3	2
CESC	Bak →	+0.181	+2.842	.006	.032	3	1
UCEC	Rab11 →	-0.139	-2.459	.047	.020	3	1
UCEC	ARID1A →	-0.183	-2.314	.045	.035	3	1
UCEC	XBP1 →	-0.270	-3.308	<.001	.009	3	1
UCEC	p62 Lck ligand →	+0.476	+2.459	.002	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Bim by MICALL2 expression — SKCM

Explore this box plot interactively →