MICALL1

Across TCGA patient cohorts, MICALL1 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MICALL1-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and A-Raf_pS299. Each is linked with MICALL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MICALL1-to-partner and partner-to-MICALL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by MICALL1-low versus MICALL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MICALL1→partner) and Y-score (partner→MICALL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.967	+3.479	<.001	.002	3	2
UCEC	EGFR_pY1068 →	-0.289	-2.807	.008	.003	3	1
UCEC	A-Raf_pS299 →	-0.143	-3.321	.006	.010	3	1
UCEC	Ku80 →	+0.279	+2.179	.006	.034	3	1
UCEC	MSH2 →	-0.284	-2.973	.004	.035	3	1
UCEC	mTOR_pS2448 →	-0.143	-3.150	.028	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Caspase-7-cleavedD198 by MICALL1 expression — UCEC

Explore this box plot interactively →