MICAL2

Across TCGA cell cohorts, MICAL2 mutation is significantly associated with the RNA expression of many other genes, with 35 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MICAL2-associated genes across cancer lineages are BPIFB6, CCDC182, and ACCSL. Each is linked with MICAL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MICAL2-to-partner and partner-to-MICAL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BPIFB6 grouped by MICAL2-low versus MICAL2-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MICAL2→partner) and Y-score (partner→MICAL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	BPIFB6 →	+0.086	+5.000	<.001	.006	3	2
BREAST	CCDC182 →	+0.051	+3.672	<.001	.006	3	2
PANCREAS	ACCSL →	+0.006	+5.614	<.001	.002	3	1
PANCREAS	MTRNR2L5 →	+0.026	+5.614	<.001	.002	3	1
URINARY_TRACT	FCN2 →	+0.033	+5.087	<.001	.004	3	1
URINARY_TRACT	PABPN1L →	+0.013	+5.087	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

BPIFB6 by MICAL2 expression — PANCREAS

Explore this box plot interactively →