MICAL1

Across TCGA patient cohorts, MICAL1 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MICAL1-associated genes across cancer lineages are eIF4E, eIF4G, and ERK2. Each is linked with MICAL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MICAL1-to-partner and partner-to-MICAL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by MICAL1-low versus MICAL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MICAL1→partner) and Y-score (partner→MICAL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.165	+2.392	.014	<.001	3	2
UCEC	eIF4G →	+0.277	+2.222	.005	.009	3	2
UCEC	ERK2 →	+0.161	+2.000	.008	.009	3	2
UCEC	p90 RSK →	+0.151	+1.290	.013	.034	3	2
SKCM	4E-BP1_pT70 →	+0.191	+2.186	.042	.034	3	2
UCEC	A-Raf_pS299 →	-0.146	-2.502	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

eIF4E by MICAL1 expression — UCEC

Explore this box plot interactively →