MICAL1

Across TCGA cell cohorts, MICAL1 mutation is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MICAL1-associated genes across cancer lineages are MC2R, MYH6, and BOD1L2. Each is linked with MICAL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MICAL1-to-partner and partner-to-MICAL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MC2R grouped by MICAL1-low versus MICAL1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MICAL1→partner) and Y-score (partner→MICAL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	MC2R →	+0.004	+4.754	<.001	.005	3	2
PANCREAS	MYH6 →	+0.006	+5.000	<.001	.006	3	1
SOFT_TISSUE	BOD1L2 →	+0.003	+3.977	<.001	.007	3	1
BONE	KRTAP22-2 →	+0.290	+5.169	<.001	.004	3	1
URINARY_TRACT	C16orf90 →	+0.023	+5.087	<.001	.004	3	1
URINARY_TRACT	OR2A2 →	+0.046	+5.087	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

MC2R by MICAL1 expression — CNS

Explore this box plot interactively →