Across TCGA patient cohorts, MICA mutation is significantly associated with the RNA expression of many other genes, with 277 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MICA-associated genes across cancer lineages are MIR7702, LINC01727, and POLDIP3. Each is linked with MICA in more than 1 cancer types. Because this analysis shows association rather than direction, both MICA-to-partner and partner-to-MICA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MICA→partner) and Y-score (partner→MICA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR7702 →	+0.338	+4.890	<.001	.002	3	1
UCEC	LINC01727 →	+0.088	+2.381	.001	.009	3	1
UCEC	POLDIP3 →	+0.612	+3.210	.004	.009	3	1
UCEC	LPIN2 →	+0.852	+3.332	.001	.005	3	1
UCEC	ACOD1 →	+0.255	+3.715	<.001	.002	3	1
UCEC	USB1 →	+0.550	+3.354	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 277 associations by consensus.

Exploration

MICA survival (RNA) · tumor vs normal (RNA) · all MICA data types