Across TCGA patient cohorts, MICA mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MICA-associated genes across cancer lineages are Ku80, Notch1, and p62 Lck ligand. Each is linked with MICA in more than 1 cancer types. Because this analysis shows association rather than direction, both MICA-to-partner and partner-to-MICA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MICA→partner) and Y-score (partner→MICA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.301	+2.817	.020	.036	3	1
UCEC	Notch1 →	+0.227	+2.820	.003	.035	3	1
UCEC	p62 Lck ligand →	+0.508	+3.169	.004	.020	3	1
UCEC	PCNA →	+0.272	+3.169	.021	.020	3	1
UCEC	PDCD4 →	-0.667	-3.169	.009	.020	3	1
UCEC	ATM →	-0.628	-3.169	.011	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

MICA survival (RNA) · tumor vs normal (RNA) · all MICA data types