Across TCGA cell cohorts, MICA RNA expression is significantly associated with the go_rna of many other GO terms, with 4,393 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible MICA-associated GO terms across cancer lineages are Negative regulation of leukocyte mediated cytotoxicity, Negative regulation of cell killing, and Negative regulation of natural killer cell mediated cytotoxicity. Each is linked with MICA in more than 15 cancer types. Because this analysis shows association rather than direction, both MICA-to-partner and partner-to-MICA results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MICA→partner) and Y-score (partner→MICA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Negative regulation of leukocyte mediated cytotoxicity →	+0.322	+1.505	<.001	.005	2	16
LUNG_NSCLC_LUSC	Negative regulation of cell killing →	+0.313	+1.455	<.001	.003	3	15
LUNG_NSCLC_LUSC	Negative regulation of natural killer cell mediated cytotoxicity →	+0.303	+1.505	<.001	.005	1	15
LUNG_NSCLC_LUSC	Negative regulation of natural killer cell mediated immunity →	+0.303	+1.505	<.001	.005	1	15
LUNG_SCLC	Negative regulation of natural killer cell activation →	+1.277	+3.199	<.001	<.001	3	13
BONE	Response to heat →	+0.101	+1.299	<.001	.005	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,393 associations by consensus.

Exploration

MICA survival (RNA) · tumor vs normal (RNA) · all MICA data types