Across TCGA patient cohorts, MIB2 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MIB2-associated genes across cancer lineages are eIF4E, Lck, and ATM. Each is linked with MIB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MIB2-to-partner and partner-to-MIB2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIB2→partner) and Y-score (partner→MIB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	eIF4E →	+0.205	+2.832	.037	.035	3	2
UCEC	Lck →	+0.262	+2.115	<.001	.017	3	2
UCEC	ATM →	-0.392	-1.765	.021	.014	3	2
COAD	G6PD →	+0.228	+2.815	.028	.036	3	1
COAD	PCNA →	+0.270	+2.820	.047	.035	3	1
COAD	RAD51 →	+0.326	+2.815	<.001	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Exploration

MIB2 survival (RNA) · tumor vs normal (RNA) · all MIB2 data types