Across TCGA cell cohorts, MIB2 mutation is significantly associated with the RNA expression of many other genes, with 522 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MIB2-associated genes across cancer lineages are CXorf49B, IL31, and GFRA4. Each is linked with MIB2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MIB2-to-partner and partner-to-MIB2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIB2→partner) and Y-score (partner→MIB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CXorf49B →	+1.443	+2.544	<.001	.007	3	3
PANCREAS	IL31 →	+0.073	+5.139	<.001	<.001	3	2
LUNG_SCLC	GFRA4 →	+0.157	+4.087	.001	.002	3	2
LUNG_SCLC	FLG2 →	+0.126	+4.432	.002	<.001	3	2
LARGE_INTESTINE	RIC8B →	+0.569	+3.409	<.001	<.001	3	2
LARGE_INTESTINE	C6orf118 →	+0.074	+1.986	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 522 associations by consensus.

Exploration

MIB2 survival (RNA) · tumor vs normal (RNA) · all MIB2 data types