MIB1

Across TCGA pan-cancer cohorts, MIB1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MIB1 data layer compared with 27 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher MIB1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MIB1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

PDAC, UCEC, and LUAD are the cancer types where MIB1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	IV	0.250	0.934	.024	17	view →
UCEC	DFS	Quartile	All	1.000	0.803	.003	12	view →
LUAD	OS	Quartile	All	0.669	1.000	.013	3	view →
HNSC	DFS	Quartile	II,III,IV	0.983	0.858	.031	2	view →
CCRCC	OS	Median	III,IV	0.831	0.617	.025	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MIB1–PDAC (DFS)

Open the PDAC breakdown →