MIB1

Across TCGA patient cohorts, MIB1 mutation is significantly associated with the total protein of many other genes, with 69 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MIB1-associated genes across cancer lineages are GAPDH, ASNS, and Caspase-7-cleavedD198. Each is linked with MIB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MIB1-to-partner and partner-to-MIB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by MIB1-low versus MIB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIB1→partner) and Y-score (partner→MIB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.331	+1.440	.030	.022	3	3
UCEC	ASNS →	+0.355	+1.523	<.001	.006	3	3
UCEC	Caspase-7-cleavedD198 →	+0.546	+1.604	.001	.005	3	3
UCEC	eIF4E →	+0.149	+1.736	.012	.006	3	2
UCEC	eIF4G →	+0.251	+1.222	.004	.011	3	2
UCEC	ERK2 →	+0.188	+1.584	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

GAPDH by MIB1 expression — UCEC

Explore this box plot interactively →