MIB1

Across TCGA cell cohorts, MIB1 mutation is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MIB1-associated genes across cancer lineages are PROP1, OR56A5, and ZSCAN1. Each is linked with MIB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MIB1-to-partner and partner-to-MIB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PROP1 grouped by MIB1-low versus MIB1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIB1→partner) and Y-score (partner→MIB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PROP1 →	+0.035	+3.704	<.001	.001	3	2
BLOOD_Leukemia	OR56A5 →	+0.018	+4.247	<.001	.004	3	2
PANCREAS	ZSCAN1 →	+0.039	+5.000	<.001	.006	3	1
PANCREAS	TBL1Y →	+0.006	+5.614	<.001	.002	3	1
BLOOD_Leukemia	BHMT →	+0.245	+4.008	<.001	.001	3	1
BLOOD_Leukemia	GPHA2 →	+0.072	+3.266	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

PROP1 by MIB1 expression — BLOOD_Leukemia

Explore this box plot interactively →