MIA2

Across TCGA cell cohorts, MIA2 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MIA2-associated genes across cancer lineages are BPY2, BPY2B, and BPY2C. Each is linked with MIA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MIA2-to-partner and partner-to-MIA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BPY2 grouped by MIA2-low versus MIA2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIA2→partner) and Y-score (partner→MIA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BPY2 →	+0.030	+6.022	<.001	.001	3	1
LARGE_INTESTINE	BPY2B →	+0.030	+6.022	<.001	.001	3	1
LARGE_INTESTINE	BPY2C →	+0.030	+6.022	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

BPY2 by MIA2 expression — LARGE_INTESTINE

Explore this box plot interactively →