MIA

Across TCGA patient cohorts, MIA RNA expression is significantly associated with the go_rna of many other GO terms, with 7,130 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible MIA-associated GO terms across cancer lineages are Antigen processing and presentation of exogenous peptide antigen via MHC class II, Regulation of granulocyte differentiation, and T cell receptor signaling pathway. Each is linked with MIA in more than 14 cancer types. Because this analysis shows association rather than direction, both MIA-to-partner and partner-to-MIA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Antigen processing and presentation of exogenous peptide antigen via MHC class II grouped by MIA-low versus MIA-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MIA→partner) and Y-score (partner→MIA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Antigen processing and presentation of exogenous peptide antigen via MHC class II →	+0.116	+1.842	<.001	<.001	3	15
ESCA	Regulation of granulocyte differentiation →	+0.063	+1.083	<.001	<.001	3	15
TGCT	T cell receptor signaling pathway →	+0.050	+0.724	<.001	<.001	3	15
ESCA	Natural killer cell degranulation →	+0.072	+1.212	<.001	<.001	3	15
STAD	Response to tumor cell →	+0.043	+1.128	<.001	<.001	3	14
ESCA	Antigen processing and presentation of exogenous peptide antigen →	+0.096	+1.570	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,130 associations by consensus.

Antigen processing and presentation of exogenous peptide antigen via MHC class II by MIA expression — ESCA

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