MIA

Across TCGA patient cohorts, MIA mutation is significantly associated with the RNA expression of many other genes, with 79 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MIA-associated genes across cancer lineages are FTLP18, LINC01066, and RPS15AP34. Each is linked with MIA in more than 1 cancer types. Because this analysis shows association rather than direction, both MIA-to-partner and partner-to-MIA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FTLP18 grouped by MIA-low versus MIA-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIA→partner) and Y-score (partner→MIA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FTLP18 →	+0.167	+6.734	<.001	<.001	3	2
COAD	LINC01066 →	+0.206	+6.409	.001	<.001	3	2
COAD	RPS15AP34 →	+0.671	+4.354	<.001	.007	3	2
COAD	MIR4472-2 →	+1.079	+4.893	<.001	.005	3	2
HNSC	MIR362 →	+0.552	+7.954	<.001	.008	3	1
UCEC	RNA5SP26 →	+0.373	+5.245	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 79 associations by consensus.

FTLP18 by MIA expression — COAD

Explore this box plot interactively →