MIA

Across TCGA cell cohorts, MIA RNA expression is significantly associated with the go_rna of many other GO terms, with 2,166 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible MIA-associated GO terms across cancer lineages are Regulation of protein processing, Regulation of mRNA stability, and Xenobiotic metabolic process. Each is linked with MIA in more than 5 cancer types. Because this analysis shows association rather than direction, both MIA-to-partner and partner-to-MIA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein processing grouped by MIA-low versus MIA-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MIA→partner) and Y-score (partner→MIA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Regulation of protein processing →	+0.094	+2.520	.001	<.001	3	6
BLOOD_Lymphoma	Regulation of mRNA stability →	+0.039	+0.594	.001	<.001	3	6
LUNG_SCLC	Xenobiotic metabolic process →	-0.059	-0.767	<.001	<.001	3	6
LARGE_INTESTINE	Maintenance of unfolded protein →	+0.077	+1.223	.003	.001	3	6
LARGE_INTESTINE	Regulation of protein deubiquitination →	+0.065	+1.336	.001	<.001	3	5
LUNG_NSCLC_LUAD	Phosphatidylcholine metabolic process →	+0.073	+1.749	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,166 associations by consensus.

Regulation of protein processing by MIA expression — PANCREAS

Explore this box plot interactively →