MGST3

Across TCGA patient cohorts, MGST3 mutation is significantly associated with the RNA expression of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MGST3-associated genes across cancer lineages are RNU6-11P, RNA5SP527, and MIR8071-2. Each is linked with MGST3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MGST3-to-partner and partner-to-MGST3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-11P grouped by MGST3-low versus MGST3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MGST3→partner) and Y-score (partner→MGST3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-11P →	+0.510	+4.531	<.001	.005	3	2
UCEC	RNA5SP527 →	+0.518	+2.939	<.001	.005	3	1
UCEC	MIR8071-2 →	+1.334	+3.712	.006	.004	3	1
UCEC	MIR6894 →	+0.890	+3.233	<.001	.002	3	1
SKCM	RPL39P28 →	+0.403	+4.594	<.001	.008	3	1
SKCM	GCSHP1 →	+0.138	+4.970	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

RNU6-11P by MGST3 expression — SKCM

Explore this box plot interactively →