MGST1

Across TCGA patient cohorts, MGST1 mutation is significantly associated with the RNA expression of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MGST1-associated genes across cancer lineages are RNU4ATAC11P, MIR548Y, and MIR3140. Each is linked with MGST1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MGST1-to-partner and partner-to-MGST1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4ATAC11P grouped by MGST1-low versus MGST1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MGST1→partner) and Y-score (partner→MGST1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU4ATAC11P →	+0.642	+2.976	.003	.005	3	2
SKCM	MIR548Y →	+0.448	+4.513	<.001	.009	3	1
SKCM	MIR3140 →	+0.390	+5.328	<.001	.003	3	1
SKCM	MIR5687 →	+0.385	+4.867	<.001	.005	3	1
SKCM	MIR3908 →	+0.314	+4.970	<.001	.005	3	1
UCEC	MIR3159 →	+0.538	+4.034	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

RNU4ATAC11P by MGST1 expression — UCEC

Explore this box plot interactively →