MGP

Across TCGA pan-cancer cohorts, MGP mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MGP data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher MGP mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated MGP expression acts as an unfavorable survival marker.

LSCC, LUAD, and GBM are the cancer types where MGP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	II,III,IV	0.590	1.000	.002	39	view →
LUAD	OS	Tertile	III,IV	0.534	1.000	.013	20	view →
GBM	DFS	Tertile	All	0.608	0.871	.002	12	view →
CCRCC	OS	Quartile	III,IV	0.140	0.830	.038	8	view →
HNSC	OS	Quartile	II,III,IV	0.932	1.000	.037	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MGP–LSCC (OS)

Open the LSCC breakdown →