MGP

Across TCGA patient cohorts, MGP mutation is significantly associated with the RNA expression of many other genes, with 1,899 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MGP-associated genes across cancer lineages are MTATP6P30, LSS, and SLC3A2. Each is linked with MGP in more than 1 cancer types. Because this analysis shows association rather than direction, both MGP-to-partner and partner-to-MGP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTATP6P30 grouped by MGP-low versus MGP-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MGP→partner) and Y-score (partner→MGP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MTATP6P30 →	+0.089	+7.954	<.001	.008	3	2
UCEC	LSS →	+0.656	+3.223	.001	.009	3	2
UCEC	SLC3A2 →	+0.657	+3.470	<.001	.002	3	2
UCEC	SMIM4 →	+0.493	+2.627	.006	.006	3	2
UCEC	CLPTM1L →	+0.480	+3.743	.005	<.001	3	2
UCEC	SCD →	+1.399	+3.480	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,899 associations by consensus.

MTATP6P30 by MGP expression — HNSC

Explore this box plot interactively →