MGP

Across TCGA patient cohorts, MGP mutation is significantly associated with the immune_cell of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MGP-associated genes across cancer lineages are Endothelial cells, lymphatic Endothelial cells, and mv Endothelial cells. Each is linked with MGP in more than 1 cancer types. Because this analysis shows association rather than direction, both MGP-to-partner and partner-to-MGP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endothelial cells grouped by MGP-low versus MGP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MGP→partner) and Y-score (partner→MGP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Endothelial cells →	-0.041	-3.161	.020	.019	3	1
UCEC	lymphatic Endothelial cells →	-0.024	-3.138	.029	.019	3	1
UCEC	mv Endothelial cells →	-0.024	-3.169	.032	.019	3	1
UCEC	Basophils →	+0.170	+3.321	.031	.010	3	1
UCEC	pDC →	+0.052	+2.839	.021	.034	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Endothelial cells by MGP expression — UCEC

Explore this box plot interactively →