MGMT

Across TCGA patient cohorts, MGMT RNA expression is significantly associated with the go_rna of many other GO terms, with 7,126 significant associations in total. PRAD shows the largest number of these associations.

The most reproducible MGMT-associated GO terms across cancer lineages are Negative regulation of telomere capping, Retrograde axonal transport, and Regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. Each is linked with MGMT in more than 17 cancer types. Because this analysis shows association rather than direction, both MGMT-to-partner and partner-to-MGMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of telomere capping grouped by MGMT-low versus MGMT-high in THYM.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MGMT→partner) and Y-score (partner→MGMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	Negative regulation of telomere capping →	-0.057	-0.666	<.001	<.001	3	18
SARC	Retrograde axonal transport →	-0.048	-0.751	<.001	<.001	3	18
THYM	Regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay →	-0.036	-0.654	<.001	<.001	3	17
THYM	Response to nerve growth factor →	-0.063	-1.046	<.001	<.001	3	17
THYM	Ribosome-associated ubiquitin-dependent protein catabolic process →	-0.077	-0.737	<.001	<.001	3	17
THYM	[4Fe-4S] cluster assembly →	+0.045	+0.780	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,126 associations by consensus.

Negative regulation of telomere capping by MGMT expression — THYM

Explore this box plot interactively →