MGMT

Across TCGA cell cohorts, MGMT RNA expression is significantly associated with the go_rna of many other GO terms, with 2,955 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MGMT-associated GO terms across cancer lineages are Negative regulation of potassium ion transmembrane transport, Aerobic electron transport chain, and Proton motive force-driven ATP synthesis. Each is linked with MGMT in more than 6 cancer types. Because this analysis shows association rather than direction, both MGMT-to-partner and partner-to-MGMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of potassium ion transmembrane transport grouped by MGMT-low versus MGMT-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MGMT→partner) and Y-score (partner→MGMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Negative regulation of potassium ion transmembrane transport →	-0.156	-2.211	.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	Aerobic electron transport chain →	+0.091	+1.971	<.001	.001	3	6
UPPER_AERODIGESTIVE_TRACT	Proton motive force-driven ATP synthesis →	+0.103	+1.730	.005	.009	3	6
OVARY	Regionalization →	-0.040	-1.550	<.001	.009	3	6
UPPER_AERODIGESTIVE_TRACT	ATP synthesis coupled electron transport →	+0.095	+1.892	<.001	.001	3	5
UPPER_AERODIGESTIVE_TRACT	Mitochondrial ATP synthesis coupled electron transport →	+0.095	+1.892	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,955 associations by consensus.

Negative regulation of potassium ion transmembrane transport by MGMT expression — OVARY

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