MGMT

Across TCGA cell cohorts, MGMT mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MGMT-associated genes across cancer lineages are BMP15, DEFA4, and SLC4A1. Each is linked with MGMT in more than 1 cancer types. Because this analysis shows association rather than direction, both MGMT-to-partner and partner-to-MGMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BMP15 grouped by MGMT-low versus MGMT-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MGMT→partner) and Y-score (partner→MGMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	BMP15 →	+0.030	+4.906	<.001	.006	3	1
LARGE_INTESTINE	DEFA4 →	+0.026	+4.022	<.001	.006	3	1
LARGE_INTESTINE	SLC4A1 →	+0.034	+3.658	.006	.005	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

BMP15 by MGMT expression — OESOPHAGUS

Explore this box plot interactively →