MGME1

Across TCGA patient cohorts, MGME1 protein abundance is significantly associated with the RNA expression of many other genes, with 17,572 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MGME1-associated genes across cancer lineages are MCM8, GINS1, and E2F1. Each is linked with MGME1 in more than 6 cancer types. Because this analysis shows association rather than direction, both MGME1-to-partner and partner-to-MGME1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MGME1 versus MCM8 in LSCC, with a Pearson correlation of 0.58.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MGME1→partner) and Y-score (partner→MGME1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MCM8 →	+0.806	+0.551	<.001	<.001	3	7
LUAD	GINS1 →	+0.974	+0.533	<.001	<.001	3	7
BRCA	E2F1 →	+1.007	+0.425	<.001	<.001	3	6
BRCA	CNRIP1 →	-0.607	-0.355	.002	<.001	3	6
UCEC	HJURP →	+0.871	+0.324	<.001	<.001	3	6
UCEC	PKMYT1 →	+0.733	+0.341	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,572 associations by consensus.

MGME1 vs MCM8 — LSCC

Explore this scatter interactively →